Every ADMET Property Explained: BBB, Caco-2, hERG, CYP450, logP

By BioDockify Computational Research Team · September 5, 2026 · ADMET

All ADMET properties explained one by one — absorption (Caco-2, P-gp, HIA), distribution (BBB, PPB), metabolism (CYP450), excretion, and toxicity flags — and how to read an ADMET report.

Read the complete article with tables, code and references on BioDockify.

Key References

• van de Waterbeemd, H. & Gifford, E. ADMET in silico modelling. Nat. Rev. Drug Discov. 2, 192-204 (2003).
• In silico ADMET prediction: recent advances, current challenges and future trends. WIREs Comput. Mol. Sci. (2013).

Scope & Limitations

Thresholds vary slightly between tools Predictions are probabilistic, not binary truth